Cure, s lijekovima protiv akni trebate biti jako oprezne ako ste trudne ili namjeravate biti! Nisu hormoni u pitanju, nego neki oblik vitamina A u velikim dozama postaje teratogen tj. može dovesti do raznih anomalija fetusa. Evo što sam našla:Citiraj:
pomikaki prvotno napisa
ISOTRETINOIN (ACCUTANE)
Results of studies on a related compound, isotretinoin initially raised concerns about vitamin A dosages in pregnancy. Isotretinoin is a 13-cis-retinoic acid used to treat severe cystic acne. This chemical has vitamin A activity. It was shown to cause major malformations in 20% of fetuses exposed during early pregnancy (Lammer et al., 1985). These malformations involved four structures: the cranium and face; the heart; the thymus; and, the brain. Isotretinoin is thought to interfere with cranial crest cells, which contribute to the development of the ear and conotruncal areas of the heart. In this study mothers took daily doses of 0.5-1.5 mg/kg/day. The relative risk for brain, cardiac, or ear malformations in exposed fetuses was 25.6 times higher than the risk for unexposed fetuses (Lammer et al., 1985).
VITAMIN A AND CONGENITAL ANOMALIES
Numerous animal studies involving vitamin A administration during pregnancy have reported teratogenic effects. Pregnant rats fed 35,000 IU/day 2-16 of gestation had an increased frequency of encephaly, cleft lip and/or palate, brachygnathia and various eye defects (Cohlan, 1953). Subsequent reports on mice, guinea pigs, hamsters, and rabbits found these species to be similarly susceptible to hypervitaminosis A. The teratogenicity of vitamin A in animals lead to the assumption that vitamin A, not beta-carotene, is a human teratogen, even though much of the direct evidence for its teratogenicity comes from anecdotal reports of mothers consuming >25,000 IU/day during pregnancy.
