Nabla, hvala za link ima dobar popis pretraga!
Samo jedna napomena, u tekstu pise:

"Tada je PCR metodom utvrdjena mutacija gena za enzim MTHFR C677T, ...kao i da je pacijentkinja homozigotni nosilac. Zbog toga je sproveden sledeci terapijski postupak: 6 meseci pre planirane eventualne naredne trudnoce propisana je terapija folnom kiselinom, vitaminom B6 i vitaminom C. Nakon utvrdjivanja trudnoce (ultrazvuk) nastavljeno je sa istom terapijom. "

Sve je to dobro, no ako kao amater smijem primijetiti u terapiji jos nedostaje B12 - na puno mjesta sam naletila na upozorenje da se terapijom samo s folnom moze zamaskirati manjak B12 i da folnu treba uzimati u kombinaciji s B12 i B6, evo objasnjenja:

"The metabolism of homocysteine, an intermediate in the metabolism of sulfur-containing amino acids, provides an example of the interrelationships among nutrients necessary for optimium physiological function and health. Healthy individuals utilize two different pathways to metabolize homocysteine (see diagram). One pathway (methionine synthase) synthesizes methionine from homocysteine and is dependent on a folate coenzyme and a vitamin B12-dependent enzyme. The other pathway converts homocysteine to another amino acid, cysteine, and requires two vitamin B6-dependent enzymes. Thus, the amount of homocysteine in the blood is regulated by three vitamins: folate, vitamin B12, and vitamin B6 (4)"

"Concerns regarding safety are limited to synthetic folic acid intake. Deficiency of vitamin B12, though often undiagnosed, may affect a significant number of people, especially older adults (see Vitamin B12). One symptom of vitamin B12 deficiency is megaloblastic anemia, which is indistinguishable from that associated with folate deficiency (see Deficiency). Large doses of folic acid given to an individual with an undiagnosed vitamin B12 deficiency could correct megaloblastic anemia without correcting the underlying vitamin B12 deficiency, leaving the individual at risk of developing irreversible neurologic damage."
Izvor: http://lpi.oregonstate.edu/infocenter/vitamins/fa/

Zbog toga na dosta mjesta kazu preventivno uzimati kombinaciju folne 400mcg, B12 6mcg i B6 2mg, a u slucaju jako povisenog homocisteina te doze znaju dosta i povecati.