Bebomanka, ne ljuti se na sebe - tu se uvijek pojavi jos nesto dodatno sto bi mozda moglo uticati, nedavno sam dobila odgovor od strucnjaka za ovo podrucje da raznorazni trombo faktori uticu tek od 10 tjedna trudnoce nadalje... no izgleda da se s PAI-1 te granice ipak pomicu i na ranije tjedne!

Isla sam malo istrazivati i pronasla sam 2 stvari vezane uz PAI-1 polimorfizam koje su "sumnjive" kod rane trudnoce:

(1) Homozygosity for PAI-1 4G or FXIII 34Leu polymorphisms as well as compound carrier status is associated with early pregnancy loss. Of the 178 first- and second-trimester pregnancy losses, 173 occurred between the 8th and 12th weeks of gestation and 5 between the 13th and 20th weeks. None of the women had experienced second-trimester pregnancy loss only.
Izvor: http://www.clinchem.org/cgi/content/full/49/7/1081

(2) "Along the same lines, Buchholz and colleagues (Hum Reprod 2003;18:2473-7) studied the ACE deletion(D)/insertion(I) and the PAI-1 4G/5G polymorphisms in women with RPL, both of which are associated with increased ACE and PAI-1 expression, respectively. Comparing 184 women with a history of two or more consecutive spontaneous abortions with 127 women who had term pregnancies and no early losses, they found that homozygosity for the D allele of the ACE gene (D/D) was significantly correlated with RPL and the presence of the PAI-1 4G/4G homozygous state further increased PAI-1 levels and risk for early pregnancy loss. As a consequence of these findings, the authors recommended “the incorporation of these two polymorphisms into the spectrum of thrombophilic mutations which should be analyzed in individuals with recurrent spontaneous miscarriages.”"
http://www.healthline.com/blogs/preg...r-1-pai-1.html

Ja sam nakon 3. pobacaja napravila "sve" osim PAI-1 ... sada intenzivno razmisljam da si tu pretragu poklonim za valentinovo

Svima velika