evo još nešto o onome što se piše već više godina-zašto naša dijagnostika NK stanica nije dovoljna i kao takva nema utjecaja:
There is little doubt that there is an ever growing recognition and acceptance of the fact that uterine immunologic dysfunction can lead to “unexplained” infertility, implantation dysfunction, unexplained IVF failure, recurrent pregnancy loss (RPL), and even placental insufficiency. Although there are many autoimmune and alloimmune factors that contribute to such implantation dysfunction, in the final analysis it is the activation of uterine natural killer cells (NKa) (and possibly cytotoxic-T cells) with the release of toxic cytokines that so damage the “root system” (trophoblast) of the embryo that the pregnancy is either immediately rejected, or placentation is compromised, causing pregnancy loss.

There are several methods whereby NKa can be assessed in the laboratory. While methods such as immunohistochemical assessment of uterine NK cells and/or TH-1 and TH-2 cytokines have been used, the gold standard remains the so called K-562 target cell test. In this test, NK cells isolated from the blood through flow Cytometry are incubated with specific target cells and thereupon, NK cell killing is measured. It is important to bear in mind that measurement of NK cell blood concentration has little or no value in assessing NKa.