http://www.rxmed.com/b.main/b2.pharmaceutical/b2.1.monographs/CPS-%20Monographs/CPS-%20(General%20Monographs-%20A)/ACCUTANE.html

Because of significant side effects associated with its use, isotretinoin should be reserved for patients where the conditions listed above are unresponsive to conventional therapy, including systemic antibiotics. Isotretinoin should only be prescribed by physicians knowledgeable in the use of retinoids systemically. It is recommended that each isotretinoin prescription be limited to preferably a 1 month supply in order to encourage patients to return for their regular appointments.
Ispod toga su i nabrojane nuspojave, a nisu ni rijetke - i do 25%.. :shock: [/quote]